Reading the immune system, one clone at a time.
Kilian Maire, immunologist specialised in Th2 lymphocyte and T-cell receptor repertoire biology. Founder & CEO of Biotraxion and KIMA Holding, building at the edge of biology and AI.
I study how the immune repertoire decides between tolerance and disease, linking clonal diversity to T-cell fate, tissue adaptation, and pathogenic potential.
As a postdoctoral researcher at the University of Copenhagen (Skin Immunology Research Center, LEO Foundation, dir. Pr. Jonathan Coquet), I investigate TCR repertoire dynamics across human and mouse models, integrating single-cell and bulk repertoire analyses with high-dimensional immunophenotyping and functional assays.
My doctoral work at INFINITY (Toulouse) uncovered filamin dosage as a control node for Th2 lymphocyte function, a mechanism now protected by a European patent and translated toward asthma therapy.
Beyond the bench, I build. As founder & CEO of Biotraxion and KIMA Holding, I drive product vision and R&D across embedded systems, computer vision and AI, taking laboratory science into regulated, real-world deployment.
Peer-reviewed work on the molecular mechanisms tuning type-2 immunity, and the therapeutic openings they reveal.
From the bench to the build, companies taking lab science into regulated practice.
Biotraxion
A traceability platform for the modern lab: from scientific problem to system architecture, regulatory strategy and go-to-market. R&D across embedded systems, computer vision, AI and cloud, built for compliance and human-machine interaction in regulated environments.
KIMA Holding
The holding behind the ventures, driving business strategy, fundraising, IP and freedom-to-operate analysis, and partnerships with academic labs, hospitals and biotech/pharma stakeholders.
Open-source tools and multi-agent AI for immune repertoires and allergy multi-omics on public data, published openly.
hillrep
Coverage-based Hill-number diversity for immune repertoires, in Python. A validated iNEXT port with AIRR and single-cell support, plus an assess() verdict on whether a diversity comparison is even valid. Published on PyPI with a citable DOI.
terminal-disorder-asymmetry
Is the reported enrichment of intrinsic disorder at protein N-termini real, or an artefact of signal peptides and AlphaFold pLDDT confidence? A preregistered, within-protein paired test across six proteomes and three disorder proxies. A clean corrective negative, with a citable DOI.
vaccine-inflammation-age
An age-dependent reversal of the baseline-inflammation to vaccine-antibody-response relationship: a meta-analytic replication in ImmuneSignatures2 with independent influenza cohorts. Fully reproducible, with a preprint and a citable DOI.
FALCO
Falsification-first multi-agent AI for reanalyzing public allergy multi-omics. A result is published only if it survives sister-allergen control, permutation null, blinded replication, and specification curve.
agentic-tcr-type2-discovery
Does the Th2 program carry a separable, replicated TCR signature on public single-cell data?
agentic-allergen-ige-germline-discovery
Is allergen-specific IgE germline-proximal and convergent across allergens on public single-cell BCR data?
TCR-Prediction
TCR MCP servers built on the IMGT database, tooling for T-cell receptor analysis and prediction workflows.
Essays on immunology, AI and what it means to build science, Le Substack de Kilian.
Read all essays on Substack ↗Ma thèse en 180 secondes , my doctoral thesis, explained to a general audience in three minutes.